Paso del Norte Health Foundation (PdNHF) leads, funds, promotes and leverages opportunities to assure that all people in its service region achieve good health. This is accomplished in part through grants and other assistance PdNHF provides to nonprofits in western Texas, Southern New Mexico, and Juarez, Chihuahua, Mexico. A principal component of this assistance is the provision of organizational strengthening or capacity building for nonprofits, with the objective of ensuring more robust financial and other management processes and increasing their ability to promote improved health outcomes for the region. To that end, PdNHF has provided training for members of non-profit boards, as well as leadership development for mid to high-level managers in health and human service organizations. PdNHF is now considering expanding this assistance to include organization-wide organizational strengthening support to regional non-profits. By providing organization-wide support to both grantees and other non-profits, PdNHF intends to improve non-profit organizational functioning and thus positively influence a range of outcomes for enhanced health and quality of life.